Black Box Warning

BOXED WARNING: Fetal/Neonatal Morbidity and Mortality — Do not use during pregnancy (Category D). Can cause fetal kidney dysfunction, oligohydramnios, hypotension, skull hypoplasia, and death. Discontinue immediately when pregnancy is detected.

What this means:A black box warning is the FDA's strongest required safety notice. It signals a serious or life-threatening risk. Patients should review this with their prescriber before starting, continuing, or switching Lisinopril.

Other warnings & precautions

Angioedema risk — can occur at any time, even years after starting. Higher risk in Black patients and those with history of angioedema. Potentially life-threatening if airway involved.
First-dose hypotension — especially in volume-depleted patients. Start with 5 mg or less in these patients.
Impaired renal function monitoring required — check serum creatinine and potassium within 1–2 weeks of initiation.
Contraindicated with history of ACE inhibitor-related angioedema.
Do not use with Entresto (sacubitril/valsartan) within 36 hours.

Black Box Warning

Other warnings & precautions

Angioedema risk — can occur at any time, even years after starting. Higher risk in Black patients and those with history of angioedema. Potentially life-threatening if airway involved.
First-dose hypotension — especially in volume-depleted patients. Start with 5 mg or less in these patients.
Impaired renal function monitoring required — check serum creatinine and potassium within 1–2 weeks of initiation.
Contraindicated with history of ACE inhibitor-related angioedema.
Do not use with Entresto (sacubitril/valsartan) within 36 hours.

Lisinopril Black Box Warning

Black Box Warning

Other warnings & precautions

Lisinopril Black Box Warning

Black Box Warning

Other warnings & precautions