8 known interactions • 6 major • 1 moderate • 1 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Potassium supplements / Potassium-sparing diuretics
Concurrent use increases risk of severe hyperkalemia. Monitor potassium levels closely.
NSAIDs (ibuprofen, naproxen)
Reduce antihypertensive efficacy and may precipitate acute kidney injury. Avoid combination if possible.
Aliskiren (in diabetes or CKD)
Dual RAAS blockade increases risk of hypotension, hyperkalemia, and renal impairment. Contraindicated.
ARBs (losartan, valsartan) — dual RAAS blockade
Combination not recommended due to increased adverse outcomes.
Lithium
ACE inhibitors can increase lithium levels, causing toxicity. Monitor lithium levels.
Sacubitril/valsartan (Entresto)
Do not use within 36 hours of each other due to risk of angioedema.
Diuretics (furosemide, hydrochlorothiazide)
Increased risk of first-dose hypotension. Start with low dose of lisinopril.
Insulin and oral antidiabetics
ACE inhibitors may enhance hypoglycemic effect. Monitor blood glucose.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Lisinopril. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.