Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
Gastrointestinal: dyspepsia, nausea, abdominal discomfort, heartburn
Diarrhea or constipation
Headache
Dizziness and drowsiness
Fluid retention and peripheral edema
Mild blood pressure elevation
Tinnitus (ringing in ears) — more common with naproxen than other NSAIDs
Gastrointestinal bleeding, ulceration, and perforation — risk increased in elderly, history of GI ulcers, corticosteroid use, anticoagulant use
Cardiovascular thrombotic events: MI and stroke (class effect; naproxen may have lower CV risk than other NSAIDs)
Acute kidney injury — particularly with volume depletion, elderly, diuretics, or ACE inhibitor use
Severe skin reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis (rare)
Hepatotoxicity (rare but reported)
Anaphylaxis and anaphylactoid reactions
Aseptic meningitis (in patients with autoimmune diseases)
Agranulocytosis, aplastic anemia (very rare)
Visual disturbances
Like all medications, Naproxen can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: