Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
Nausea (23–35%) — most common; usually resolves within 2 weeks
Dry mouth (11–15%)
Headache (13–14%)
Dizziness (9–10%)
Fatigue (10–14%)
Constipation (10–11%)
Decreased appetite (6–8%)
Sweating (6%)
Serotonin syndrome (with serotonergic medicines or MAOIs)
Suicidal ideation (black box warning in <24 years)
Hepatotoxicity (avoid in liver disease patients; rare but serious)
Hypertension (norepinephrine activity; monitor BP)
Severe skin reactions (Stevens-Johnson syndrome — very rare)
SIADH/hyponatremia
Urinary retention (noradrenergic effects)
Angle-closure glaucoma
Falls in elderly (dizziness)
Like all medications, Duloxetine can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: