Complete dosing information for duloxetine hydrochloride
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
MDD: 60mg once daily; may start 30mg once daily for 1 week to improve tolerance; GAD: 60mg once daily (30–120mg range); Diabetic neuropathy: 60mg once daily; Fibromyalgia: 30mg once daily for 1 week; then 60mg once daily; Chronic musculoskeletal pain: 60mg once daily
GAD (7–17 years): 30mg once daily; may increase to 60mg.
Avoid in severe renal impairment (CrCl <30 mL/min); not recommended for end-stage renal disease.
Avoid in substantial hepatic impairment (Child-Pugh B or C).