10 known interactions • 6 major • 4 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Warfarin
Amiodarone inhibits CYP2C9 and CYP3A4, increasing warfarin levels and INR. Reduce warfarin dose by 30-50% and monitor INR closely.
Digoxin
Amiodarone increases digoxin levels by approximately 70% through P-glycoprotein inhibition. Reduce digoxin dose by 50% and monitor serum levels.
Simvastatin
CYP3A4 inhibition raises simvastatin exposure and increases risk of myopathy and rhabdomyolysis. Limit simvastatin to 20 mg daily.
Sofosbuvir
Coadministration may cause symptomatic bradycardia, sometimes requiring pacemaker. Avoid combination.
Cyclosporine
Increases cyclosporine concentrations; monitor levels and renal function.
Quinolones (ciprofloxacin, levofloxacin)
Additive QT prolongation increases risk of torsades de pointes.
Grapefruit juice
Inhibits intestinal CYP3A4, increasing oral amiodarone exposure. Avoid grapefruit products.
Beta-blockers
Additive negative chronotropic and dromotropic effects; monitor for bradycardia and heart block.
Calcium channel blockers (verapamil, diltiazem)
Additive AV nodal suppression and risk of bradyarrhythmias.
Phenytoin
Amiodarone raises phenytoin levels; phenytoin can also reduce amiodarone exposure via CYP3A4 induction.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Amiodarone. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.