Complete dosing information for Amiodarone hydrochloride
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
Oral loading: 800-1600 mg/day in divided doses for 1-3 weeks until response, then 600-800 mg/day for 1 month, then maintenance 200-400 mg/day. IV loading: 150 mg over 10 minutes, then 1 mg/min for 6 hours, then 0.5 mg/min for 18 hours. Pulseless VF/VT: 300 mg IV/IO push, may repeat 150 mg.
Not FDA-approved for pediatric use. Off-label PALS: 5 mg/kg IV/IO bolus for pulseless arrest, may repeat up to 15 mg/kg/day max.
No dose adjustment typically required; metabolites may accumulate but rarely clinically significant.
Use with caution; reduce dose if hepatic enzymes exceed 3x upper limit of normal or if clinical hepatitis develops.