7 known interactions • 4 major • 2 moderate • 1 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Rifampin (rifampicin)
Potent CYP3A4 inducer — markedly reduces COC hormone levels, causing contraceptive failure. Use alternative or additional contraception.
Anticonvulsants (carbamazepine, phenytoin, phenobarbital, topiramate)
Hepatic enzyme inducers reduce COC efficacy. Use backup contraception or alternative method.
St. John's Wort
Herbal CYP inducer — reduces COC blood levels and contraceptive reliability.
HIV antiretrovirals (ritonavir, nelfinavir)
Some antiretrovirals induce CYP3A4, reducing COC efficacy. Check specific agent interactions.
ACE inhibitors, ARBs, potassium-sparing diuretics, NSAIDs, heparin
Drospirenone has anti-mineralocorticoid activity — concurrent use increases hyperkalemia risk. Check potassium in at-risk patients.
Lamotrigine
COCs significantly reduce lamotrigine levels via glucuronidation induction, potentially reducing seizure control. Monitor lamotrigine levels.
Antibiotics (ampicillin, tetracyclines, fluoroquinolones)
Theoretical concern: gut bacteria disruption may reduce estrogen enterohepatic recycling. Evidence is weak; backup contraception during antibiotic course is recommended by some guidelines.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Yaz. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.