Complete dosing information for Ticlopidine
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
For stroke risk reduction: 250 mg orally twice daily, taken with food to improve absorption and reduce gastrointestinal upset. For prevention of coronary stent thrombosis: 250 mg twice daily in combination with antiplatelet doses of aspirin, started after successful stent placement and continued for up to 30 days. Mandatory complete blood count (CBC) monitoring with differential every two weeks from the start of therapy through the end of the third month is required because of the risk of neutropenia and TTP.
Safety and effectiveness in patients younger than 18 years have not been established. Ticlopidine is not recommended for pediatric use.
There is limited experience in patients with renal impairment. Plasma clearance is reduced and AUC increased in patients with declining renal function. No specific dose adjustment is established, but dose reduction or discontinuation should be considered if hemorrhagic or hematopoietic problems are encountered, and these patients should be monitored closely.
Ticlopidine is extensively metabolized by the liver. It is contraindicated in patients with severe hepatic impairment. Use with caution in mild to moderate hepatic dysfunction, with close monitoring of liver function and blood counts.