Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
Hyperkalemia (most important — can be life-threatening)
Gynecomastia in men (dose-dependent — via anti-androgen effects)
Menstrual irregularities in women
Breast tenderness (men and women)
GI upset, nausea, vomiting
Dizziness, headache
Severe hyperkalemia (can cause cardiac arrhythmias and death)
Hyponatremia (especially in cirrhotic patients)
Acute kidney injury (volume depletion)
Agranulocytosis (rare)
Hepatotoxicity
SLE-like syndrome
Carcinogenicity (rodent studies at high doses — not confirmed clinically)
Like all medications, Spironolactone can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: