4 known interactions • 1 major • 2 moderate • 1 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Live vaccines
Risankizumab (IL-23 inhibitor) may impair immune response to live vaccines and cause disseminated disease.
Management: Complete all live vaccinations ≥4 weeks before starting Skyrizi. Avoid during treatment.
Other immunosuppressants (cyclosporine, azathioprine, methotrexate)
Additive immunosuppression raises infection risk.
Management: Use with caution; monitor for serious or opportunistic infections.
Other biologic DMARDs (TNF inhibitors, IL-17 inhibitors, JAK inhibitors)
Combining biologics with different mechanisms increases immunosuppression; safety not established.
Management: Avoid concurrent biologic therapy. Transition therapy with appropriate washout.
CYP450 substrates (cyclosporine, warfarin, oral contraceptives)
IL-23 inhibition may modestly restore CYP450 activity suppressed by chronic inflammation, altering levels of CYP-metabolized drugs.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Skyrizi. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.