Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
Hyperprolactinemia — galactorrhea, amenorrhea, gynecomastia, sexual dysfunction, decreased libido (most prolactin-elevating of atypical antipsychotics)
Extrapyramidal symptoms (EPS) — akathisia, parkinsonism, dystonia (more than other atypicals, less than typicals; dose-dependent above 6mg/day)
Somnolence and sedation
Weight gain (moderate — less than olanzapine/quetiapine, more than aripiprazole/ziprasidone)
Metabolic effects — increased blood glucose, dyslipidemia (less than olanzapine)
Orthostatic hypotension (especially initial doses)
Constipation
Nausea
Tardive dyskinesia (TD) — potentially irreversible involuntary movements with long-term use
Neuroleptic malignant syndrome (NMS) — rare, potentially fatal
Hyperglycemia and new-onset diabetes mellitus
QTc prolongation (moderate risk)
Priapism (rare but serious)
Stroke and transient ischemic attacks (elderly patients with dementia — black box warning)
Agranulocytosis
Leukopenia, neutropenia
Seizures
Severe skin reactions
Water intoxication (SIADH)
Like all medications, Risperidone can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: