3 known interactions • 3 major • 0 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
NSAIDs
Increased methotrexate levels and toxicity
Management: Avoid combination or monitor closely
Trimethoprim/Sulfamethoxazole
Increased methotrexate levels
Management: Avoid combination
Folic acid antagonists
Increased methotrexate toxicity
Management: Avoid other folate antagonists
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Methotrexate. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.