Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
Dizziness (10–12%)
Somnolence/drowsiness (6–8%)
Nausea (5–7%)
Headache (5–7%)
Constipation (4–6%)
Pruritus/itching (4–5%)
Rash (3–5%)
Fatigue (3–4%)
Vomiting (3–4%)
Muscle spasms (2–4%)
Hypoesthesia/numbness (2–3%)
Hot flush (2–3%)
Paresthesia (2–3%)
Increased blood creatinine (2–3%)
Severe hypersensitivity reactions including anaphylaxis and angioedema — discontinue immediately and provide appropriate emergency treatment
Serious skin reactions (e.g., drug rash with eosinophilia and systemic symptoms [DRESS]) — monitor for systemic involvement and discontinue if suspected
Severe allergic dermatitis — requires prompt evaluation and potential discontinuation
Significant drug interactions with CYP3A inhibitors leading to substantially elevated suzetrigine exposure and increased toxicity risk
Liver enzyme elevations — monitor liver function in patients with hepatic impairment
Neurological adverse effects (severe dizziness, altered mental status) at supratherapeutic exposures due to drug interactions
Urticaria (hives)
Erythema multiforme
Peripheral edema
Tinnitus
Visual disturbances
Palpitations
Syncope (fainting)
Like all medications, Journavx can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: