5 known interactions • 0 major • 5 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Insulin
Increased risk of hypoglycemia. Consider reducing insulin dose when initiating Jardiance.
Sulfonylureas (glipizide, glimepiride)
Additive hypoglycemia risk. May require sulfonylurea dose reduction.
Diuretics (furosemide, hydrochlorothiazide)
Additive diuretic effect; increased risk of volume depletion, hypotension, and electrolyte imbalances.
ACE inhibitors / ARBs
Additive blood pressure lowering; increased risk of acute kidney injury with volume depletion.
Rifampin
Rifampin reduces empagliflozin exposure by ~35%. Consider dose increase or alternative therapy.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Jardiance. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.