4 known interactions • 1 major • 2 moderate • 1 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
QTc-prolonging medicines (azithromycin, fluoroquinolones, antiarrhythmics, antipsychotics)
Hydroxychloroquine prolongs the QTc interval. Combining with other QTc-prolonging medicines significantly increases risk of life-threatening torsades de pointes and ventricular arrhythmias.
Management: Avoid combining QTc-prolonging medicines when possible. Monitor ECG. Correct electrolytes (K+, Mg2+).
Insulin / sulfonylureas / other antidiabetics
Hydroxychloroquine enhances insulin sensitivity and may potentiate hypoglycemic effects, causing severe hypoglycemia.
Management: Monitor blood glucose closely; dose reduction of antidiabetic medications may be needed.
Digoxin
Hydroxychloroquine may increase digoxin plasma levels by reducing renal digoxin clearance.
Management: Monitor digoxin levels and for signs of toxicity (bradycardia, visual changes).
Antacids (especially containing aluminum or magnesium)
Antacids may reduce absorption of hydroxychloroquine.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Hydroxychloroquine. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.