Complete dosing information for hydroxychloroquine sulfate
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
Rheumatoid arthritis: 400–600mg/day initially; maintenance 200–400mg/day. CRITICAL: Max dose ≤5mg/kg/day ACTUAL body weight to minimize retinal toxicity; SLE: 200–400mg/day; max ≤5mg/kg/day actual body weight; Malaria prophylaxis: 400mg once weekly starting 2 weeks before travel; continue 4 weeks after leaving endemic area; Malaria treatment: 800mg initially, then 400mg at 6 hours, then 400mg/day for 2 more days
Rheumatoid arthritis/SLE: ≤5mg/kg/day actual body weight (max 400mg/day). Malaria prophylaxis: 6.5mg/kg once weekly (max 400mg/dose).
Use with caution in severe renal impairment; dose reduction may be needed. Monitor for accumulation.
Use with caution in hepatic disease; dose reduction may be considered.