4 known interactions • 1 major • 3 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
NSAIDs, sulfonamides, fluoroquinolones, warfarin, antifungals (fluconazole)
These agents enhance sulfonylurea hypoglycemic effect via displacement from protein binding and CYP2C9 inhibition (glipizide is CYP2C9 substrate), increasing risk of severe hypoglycemia.
Management: Monitor blood glucose closely when adding any of these agents. Dose reduction of glipizide may be needed.
Beta-blockers
Beta-blockers mask hypoglycemia symptoms (tachycardia) and may prolong hypoglycemic episodes.
Management: Monitor glucose carefully; educate patient that sweating may still occur as a hypoglycemia warning.
Corticosteroids
Steroids cause hyperglycemia, antagonizing antidiabetic effects. Dose increase of glipizide may be needed.
Management: Monitor blood glucose closely; anticipate need for dose adjustment.
Alcohol
Acute alcohol ingestion enhances hypoglycemia. Chronic alcohol use induces CYP2C9, reducing glipizide levels.
Management: Counsel patients about alcohol and hypoglycemia risk.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Glipizide. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.