Complete dosing information for glipizide
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
Immediate release (Glucotrol): 5mg once daily 30 min before breakfast; may increase by 2.5–5mg every few days; max 40mg/day (give in divided doses if >15mg); Extended release (Glucotrol XL): 5mg once daily with breakfast; may increase by 5mg every 3 months; max 20mg/day
Not FDA-approved for pediatric use.
Use with caution in moderate renal impairment; avoid in severe renal impairment (CrCl <10 mL/min) — risk of hypoglycemia from accumulation.
Start at lowest dose (2.5mg). Impaired metabolism increases hypoglycemia risk.