4 known interactions • 1 major • 2 moderate • 1 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
CNS depressants (opioids, benzodiazepines, alcohol, barbiturates)
Significantly increased risk of respiratory depression, sedation, and death. Gabapentin + opioids have been implicated in overdose deaths.
Management: Avoid or use with extreme caution. The FDA issued a safety communication in 2019. Monitor respiratory function.
Hydrocodone
Gabapentin increases hydrocodone AUC by 14% and Cmax by 3%. Additive CNS depression.
Management: Reduce opioid doses; monitor for respiratory depression.
Morphine
Morphine increases gabapentin peak concentration by 44%. Increased sedation and respiratory risk.
Management: Reduce gabapentin dose; monitor closely.
Antacids (aluminum/magnesium)
Antacids reduce gabapentin bioavailability by ~20%.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Gabapentin. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.