3 known interactions • 3 major • 0 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
ACE inhibitors
Increased hyperkalemia risk
Management: Avoid combination
Potassium-sparing diuretics
Risk of hyperkalemia
Management: Monitor potassium and renal function
NSAIDs
Risk of renal failure and hyperkalemia
Management: Avoid combination or monitor renal function
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Entresto. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.