3 known interactions • 1 major • 2 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
CNS depressants / opioids / alcohol
Additive CNS and respiratory depression. Fatal respiratory depression possible with opioid combination.
Management: Avoid combination. FDA boxed warning for benzodiazepine + opioid co-prescribing.
CYP3A4 inducers (carbamazepine, phenytoin, rifampin)
CYP3A4 inducers reduce clonazepam levels, potentially reducing seizure control.
Management: Monitor seizure control; dose adjustments may be needed.
Valproic acid
Combination may cause absence status epilepticus in patients with absence seizures.
Management: Use with caution; avoid combination in absence epilepsy if possible.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Clonazepam. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.