3 known interactions • 1 major • 2 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
QTc-prolonging medicines (amiodarone, sotalol, haloperidol, hydroxychloroquine)
Additive QTc prolongation — significantly increased risk of torsades de pointes and fatal arrhythmias.
Management: Avoid combination. If unavoidable, ECG monitoring required. Assess baseline QTc before prescribing.
Warfarin
Azithromycin can increase INR in warfarin patients, likely via gut flora suppression reducing vitamin K.
Management: Monitor INR within 3–5 days of starting azithromycin course.
Digoxin
Some macrolides alter gut flora, increasing digoxin absorption from non-absorbing forms. Elevated digoxin levels possible.
Management: Monitor digoxin levels and signs of toxicity during azithromycin course.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Azithromycin. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.