5 known interactions • 0 major • 3 moderate • 2 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Simvastatin
Amlodipine inhibits CYP3A4, increasing simvastatin exposure by ~77%. Increased risk of myopathy.
Management: FDA recommends limiting simvastatin to 20mg/day with amlodipine.
Cyclosporine
Amlodipine increases cyclosporine blood levels. Monitor closely.
Management: Monitor cyclosporine levels; dose reduction of cyclosporine may be needed.
Tacrolimus
Amlodipine may increase tacrolimus exposure via CYP3A4 inhibition.
Management: Monitor tacrolimus levels.
Sildenafil / PDE5 inhibitors
Additive blood pressure lowering effect. May cause symptomatic hypotension.
NSAIDs (chronic use)
NSAIDs can reduce antihypertensive effect of amlodipine through sodium/fluid retention.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Amlodipine. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.