5 known interactions • 1 major • 3 moderate • 1 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Beta-blockers (propranolol, metoprolol, atenolol)
Beta-blockers antagonize the bronchodilatory effects of albuterol. Non-selective beta-blockers (propranolol) are particularly problematic; cardioselective beta-1 blockers (metoprolol) are safer but still partially antagonize.
Management: Avoid non-selective beta-blockers in asthma. If cardioselective beta-blocker is needed, monitor carefully.
MAOIs / tricyclic antidepressants
May enhance cardiovascular effects of albuterol (tachycardia, hypertension).
Management: Use with extreme caution within 2 weeks of MAOI use.
Digoxin
Albuterol-induced hypokalemia can increase digoxin toxicity (hypokalemia sensitizes the myocardium to digoxin).
Management: Monitor serum potassium and digoxin levels, especially with high-dose nebulization.
Other sympathomimetics (epinephrine, pseudoephedrine)
Additive cardiovascular effects — tachycardia, hypertension, arrhythmias.
Management: Use with caution; monitor heart rate and blood pressure.
Loop diuretics (furosemide)
Additive hypokalemia — both albuterol and loop diuretics lower potassium.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Albuterol. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.