Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
Rare at therapeutic doses — remarkably well tolerated
Mild nausea (uncommon)
Rash (rare allergic reaction)
Hepatotoxicity — acute liver failure with overdose (most important toxicity; NAPQI accumulation depletes glutathione)
Acute kidney injury with chronic high-dose use or overdose
Serious skin reactions (rare): Stevens-Johnson syndrome, toxic epidermal necrolysis
Thrombocytopenia (very rare)
Agranulocytosis (extremely rare)
Anaphylaxis/hypersensitivity
Like all medications, Acetaminophen can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: