Complete dosing information for acetaminophen (paracetamol)
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
OTC dosing: 325–650mg every 4–6 hours; maximum 3,000mg/day (OTC) or 4,000mg/day (under physician supervision); IV (Ofirmev): 1,000mg every 6 hours or 650mg every 4 hours; max 4g/day; Extended-release (Tylenol 8-Hour): 1,300mg every 8 hours; max 3,900mg/day; Liver risk patients / elderly: Max 2,000mg/day (chronic alcohol use: 2,000mg/day maximum)
10–15mg/kg every 4–6 hours as needed; max 75mg/kg/day (not to exceed adult max). Weight-based dosing tables on packaging.
Mild-moderate impairment: interval extension recommended (every 8h). Avoid in severe renal impairment (CrCl <30 mL/min) with frequent use.
Use with extreme caution or avoid in severe hepatic impairment, active liver disease, or patients with chronic alcohol abuse (>3 drinks/day). Max 2g/day if used.