3 known interactions • 2 major • 1 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
CNS depressants / opioids / alcohol
Profound additive CNS and respiratory depression.
Management: Absolutely avoid alcohol. Use extreme caution with other CNS depressants.
CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir)
Markedly increase zolpidem exposure and duration of sedation.
Management: Reduce zolpidem dose by 50%; monitor for excessive sedation.
Rifampin (CYP3A4 inducer)
Dramatically reduces zolpidem plasma levels (AUC reduced by ~73%), potentially rendering it ineffective.
Management: Consider alternative hypnotic or increase zolpidem dose carefully.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Zolpidem. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.