3 known interactions • 2 major • 1 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Opioids
Risk of severe respiratory depression and death
Management: Avoid combination if possible; if necessary, use lowest doses with monitoring
Alcohol
Severe CNS depression
Management: Avoid alcohol completely
CYP3A4 inhibitors
Increased alprazolam levels
Management: Monitor for side effects
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Xanax. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.