3 known interactions • 1 major • 2 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
MAO inhibitors
Risk of serotonin syndrome and hypertensive crisis
Management: Avoid combination; wait 14 days after stopping MAOI
CYP2D6 inhibitors
May increase bupropion levels
Management: Monitor for side effects
Alcohol
Increased seizure risk
Management: Limit or avoid alcohol
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Wellbutrin. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.