6 known interactions • 2 major • 4 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Insulin
Combination substantially increases hypoglycemia risk.
Management: Reduce basal insulin dose by 20% at initiation; monitor blood glucose closely.
Other GLP-1 receptor agonists
Liraglutide is a GLP-1 agonist; combining with another GLP-1 agonist duplicates mechanism with no added benefit.
Management: Contraindicated. Use only one GLP-1 agonist.
Sulfonylureas (glyburide, glipizide)
Additive glucose-lowering increases hypoglycemia risk.
Management: Consider 50% sulfonylurea dose reduction; monitor blood glucose.
Oral medications with narrow therapeutic window
Delayed gastric emptying reduces absorption rate and peak plasma concentrations of oral drugs.
Management: Take narrow-index oral drugs ≥1 hour before liraglutide injection; monitor drug efficacy.
Warfarin
Delayed gastric emptying and GI motility changes may alter warfarin absorption and INR.
Management: Monitor INR at initiation and during dose titration.
Alcohol
May worsen nausea/vomiting side effects and exacerbate hypoglycemia risk.
Management: Advise limiting alcohol intake.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Victoza. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.