Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS The following reactions were reported with verapamil hydrochloride injection used in controlled U.S.
clinical trials involving 324 patients: Cardiovascular: Symptomatic hypotension (1.5%);
bradycardia (1.2%);
severe tachycardia (1.0%).
The worldwide experience in open clinical trials in more than 7,900 patients was similar.
Central Nervous System Effects: Dizziness (1.2%);
headache (1.2%).
Occasional cases of seizures during verapamil injection have been reported.
Gastrointestinal: Nausea (0.9%);
abdominal discomfort (0.6%).
WARNINGS VERAPAMIL HYDROCHLORIDE SHOULD BE GIVEN AS A SLOW INTRAVENOUS INJECTION OVER AT LEAST A TWO-MINUTE PERIOD OF TIME (see DOSAGE AND ADMINISTRATION).
Hypotension: Verapamil hydrochloride injection often produces a decrease in blood pressure below baseline levels that is usually transient and asymptomatic but may result in dizziness.
Systolic pressure less than 90 mm Hg and/or diastolic pressure less than 60 mm Hg was seen in 5% to 10% of patients in controlled U.S.
trials in supraventricular tachycardia and in about 10% of the patients with atrial flutter/fibrillation.
The incidence of symptomatic hypotension observed in studies conducted in the U.S.
Like all medications, Verapamil Hci can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: