4 known interactions • 2 major • 2 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
ACE inhibitors / aliskiren
Dual blockade of renin-angiotensin system increases risk of hypotension, hyperkalemia, and acute kidney injury without additional cardiovascular benefit.
Management: Avoid dual RAAS blockade (ARB + ACEi combination). Aliskiren is contraindicated with ARBs in diabetic patients.
Potassium-sparing diuretics / potassium supplements / trimethoprim
Additive hyperkalemia risk — ARBs reduce aldosterone-mediated potassium excretion.
Management: Monitor potassium closely; avoid potassium supplementation unless documented hypokalemia.
NSAIDs
NSAIDs reduce antihypertensive effect and increase risk of acute kidney injury (triple whammy with diuretic).
Management: Avoid NSAIDs in patients on ARBs + diuretics. Use acetaminophen for pain.
Lithium
ARBs reduce renal lithium clearance, increasing lithium levels and toxicity risk.
Management: Monitor lithium levels when starting valsartan.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Valsartan. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.