Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS Clinical experience with trientine hydrochloride has been limited.
The following adverse reactions have been reported in a clinical study in patients with Wilson's disease who were on therapy with trientine hydrochloride: iron deficiency, systemic lupus erythematosus (see CLINICAL PHARMACOLOGY ).
In addition, the following adverse reactions have been reported in marketed use: dystonia, muscular spasm, myasthenia gravis.
Trientine hydrochloride is not indicated for treatment of biliary cirrhosis, but in one study of 4 patients treated with trientine hydrochloride for primary biliary cirrhosis, the following adverse reactions were reported: heartburn;
epigastric pain and tenderness;
thickening, fissuring and flaking of the skin;
hypochromic microcytic anemia;
acute gastritis;
aphthoid ulcers;
abdominal pain;
WARNINGS Patient experience with trientine hydrochloride is limited (see CLINICAL PHARMACOLOGY ).
Patients receiving trientine hydrochloride should remain under regular medical supervision throughout the period of drug administration.
Patients (especially women) should be closely monitored for evidence of iron deficiency anemia.
Like all medications, Trientine Hydrochloride can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: