Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
6 ADVERSE REACTIONS The following clinically significant adverse reactions are described elsewhere in the labeling: New Primary Malignancies [see Warnings and Precautions ( 5.1)] Hemorrhage [see Warnings and Precautions (5.2)] Colitis and Gastrointestinal Perforation [see Warnings and Precautions (5.3)] Venous Thromboembolic Events [see Warnings and Precautions (
4 )] Cardiomyopathy [see Warnings and Precautions (
5 )] Ocular Toxicities [see Warnings and Precautions (
6 )] Interstitial Lung Disease/Pneumonitis [see Warnings and Precautions (
7 )] Serious Febrile Reactions [see Warnings and Precautions (
8 )] Serious Skin Toxicities [see Warnings and Precautions (
9 )] Hyperglycemia [see Warnings and Precautions (
10 )] Hemophagocytic Lymphohistiocytosis [see Warnings and Precautions (
12 )] There are additional adverse reactions associated with dabrafenib.
Refer to the dabrafenib prescribing information for additional information.
5 WARNINGS AND PRECAUTIONS New Primary Malignancies, Cutaneous and Non-Cutaneous : Can occur when MEKINIST is used with dabrafenib.
Monitor patients for new malignancies prior to, or while on therapy, and following discontinuation of treatment.
( 5.1 ) Hemorrhage : Major hemorrhagic events can occur.
Monitor for signs and symptoms of bleeding.
( 5.2 ) Colitis and Gastrointestinal Perforation : Colitis and gastrointestinal perforation can occur in patients receiving MEKINIST.
Like all medications, Mekinist can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: