Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS Gastrointestinal: anorexia, nausea, epigastric distress, vomiting, diarrhea, glossitis, black hairy tongue, dysphagia, enterocolitis, and inflammatory lesions (with Candida overgrowth) in the anogenital region.
Esophagitis and esophageal ulceration have been reported in patients receiving particularly the capsule and also the tablet forms of tetracyclines.
Most of the patients were reported to have taken medication immediately before going to bed (see DOSAGE AND ADMINISTRATION ).
Teeth : permanent discoloration of teeth may be caused during tooth development.
Enamel hypoplasia has been reported (see WARNINGS ).
Skin : fixed drug eruption, maculopapular and erythematous rashes.
Exfoliative dermatitis has been reported.
Onycholysis and discoloration of the nails have been reported.
Photosensitivity is discussed in WARNINGS .
Renal Toxicity : an increase in BUN has been reported and is dose related.
WARNINGS Tooth Development The use of drugs of the tetracycline-class during tooth development (last half of pregnancy, infancy and childhood to the age of 8 years) may cause permanent discoloration of the teeth (yellow-gray-brown).
This adverse reaction is more common during long-term use of the drugs but it has been observed following repeated short-term courses.
Enamel hypoplasia has also been reported.
Tetracycline drugs should not be used in this age group, except for anthrax, unless other drugs are not likely to be effective or are contraindicated.
Clostridium difficile Associated Diarrhea Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including tetracyclines, and may range in severity from mild diarrhea to fatal colitis.
Like all medications, Tetracycline Hydrochloride can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: