Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS Endocrine and Urogenital, Female – The most common side effects of androgen therapy are amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement.
The latter usually is not reversible after androgens are discontinued.
When administered to a pregnant woman, androgens cause virilization of the external genitalia of the female fetus.
Male – Gynecomastia, and excessive frequency and duration of penile erections.
Oligospermia may occur at high dosages (see CLINICAL PHARMACOLOGY ).
Skin and Appendages – Hirsutism, male pattern baldness, and acne.
Cardiovascular Disorders – myocardial infarction, stroke Fluid and Electrolyte Disturbances – Retention of sodium, chloride, water, potassium, calcium (see WARNINGS ), and inorganic phosphates.
Gastrointestinal – Nausea, cholestatic jaundice, alterations in liver function tests;
rarely, hepatocellular neoplasms, peliosis hepatis (see WARNINGS ).
Hematologic – Suppression of clotting factors II, V, VII, and X;
WARNINGS In patients with breast cancer and in immobilized patients, androgen therapy may cause hypercalcemia by stimulating osteolysis.
In patients with cancer, hypercalcemia may indicate progression of bony metastasis.
If hypercalcemia occurs, the drug should be discontinued and appropriate measures instituted.
Prolonged use of high doses of androgens has been associated with the development of peliosis hepatis and hepatic neoplasms including hepatocellular carcinoma (see PRECAUTIONS, Carcinogenesis ).
Peliosis hepatis can be a life-threatening or fatal complication.
Like all medications, Testosterone Enanthate can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: