5 known interactions • 2 major • 3 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Insulin / insulin secretagogues (sulfonylureas)
Liraglutide increases insulin secretion; concurrent use with insulin or sulfonylurea substantially increases hypoglycemia risk.
Management: Reduce or discontinue sulfonylurea or insulin when starting Saxenda; monitor glucose closely.
Other GLP-1 receptor agonists (semaglutide, dulaglutide, exenatide)
Pharmacological duplication — additive GI toxicity and hypoglycemia risk with no additional benefit.
Management: Contraindicated. Use only one GLP-1 agonist at a time.
Oral medications (levothyroxine, oral contraceptives)
Delayed gastric emptying may reduce absorption of orally administered drugs.
Management: Take time-sensitive oral drugs at a consistent time relative to Saxenda injection; monitor drug efficacy.
Warfarin
Delayed gastric emptying may alter warfarin absorption kinetics, affecting INR stability.
Management: Monitor INR when initiating or adjusting liraglutide dose.
Alcohol
Alcohol may worsen GI side effects (nausea, vomiting) and risk hypoglycemia in patients on concurrent antidiabetic therapy.
Management: Advise patients to limit alcohol intake.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Saxenda. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.