2 known interactions • 1 major • 1 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our free drug interaction checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Oral medications requiring absorption
Delayed gastric emptying affects absorption of oral medications
Management: Separate administration by at least 30 minutes; monitor effectiveness
Sulfonylureas
Increased hypoglycemia risk
Management: May require dose reduction
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Rybelsus. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.