12 known interactions • 7 major • 5 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Ketoconazole
Strong CYP3A4 inhibitor — concomitant use is contraindicated; markedly increases rimegepant exposure.
Itraconazole
Strong CYP3A4 inhibitor; avoid concomitant use.
Clarithromycin
Strong CYP3A4 inhibitor; avoid concomitant administration.
Rifampin
Strong CYP3A4 inducer — substantially decreases rimegepant plasma levels and reduces efficacy; avoid use.
Phenytoin
Strong CYP3A4 inducer; concurrent use should be avoided.
Carbamazepine
CYP3A4 inducer that lowers rimegepant exposure; avoid use.
St. John's Wort
Herbal CYP3A4 inducer that decreases rimegepant effectiveness.
Fluconazole
Moderate CYP3A4 inhibitor — avoid a second 75 mg dose within 48 hours.
Diltiazem
Moderate CYP3A4 inhibitor — avoid repeat doses within 48 hours.
Verapamil
Moderate CYP3A4 inhibitor; use caution and avoid second dose within 48 hours.
Cyclosporine
P-glycoprotein and BCRP inhibitor; may increase rimegepant exposure — avoid second dose within 48 hours.
Efavirenz
Moderate CYP3A4 inducer that may reduce rimegepant efficacy.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Rimegepant. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.