5 known interactions • 0 major • 0 moderate • 5 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Statins (atorvastatin, rosuvastatin, simvastatin)
No pharmacokinetic interaction; evolocumab and statins work via complementary mechanisms (PCSK9i + HMG-CoA reductase inhibition) and are intentionally combined.
Ezetimibe
Complementary LDL-lowering mechanisms (intestinal absorption blockade + PCSK9 inhibition); no interaction.
Fibrates (fenofibrate, gemfibrozil)
No significant pharmacokinetic interaction; combination may be used for mixed dyslipidemia.
Anticoagulants (warfarin)
No direct pharmacokinetic interaction with evolocumab.
Niacin (≥1 g/day)
Combination may further lower LDL-C without significant pharmacokinetic interaction.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Repatha. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.