Complete dosing information for RAXIBACUMAB
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
2 DOSAGE AND ADMINISTRATION • Premedicate with diphenhydramine. ( 2.1 , 2.2 , 5.1 ) • Dilute and administer as an intravenous infusion over 2 hours and 15 minutes. ( 2.3 ) • - Adults: 40 mg/kg raxibacumab. ( 2.1 ) • - Pediatrics greater than 40 kg: 40 mg/kg raxibacumab. ( 2.2 ) • - Pediatrics greater than 10 kg to 40 kg: 60 mg/kg raxibacumab. ( 2.2 ) • - Pediatrics 10 kg or less: 80 mg/kg raxibacumab. ( 2.2 ) 2.1 Dose and Schedule for Adults Administer raxibacumab as a single dose of 40 mg/kg intravenously over 2 hours and 15 minutes after dilution in 0.9% Sodium Chloride Injection, USP (normal saline) to a final volume of 250 mL. Administer 25 to 50 mg diphenhydramine within 1 hour prior to the raxibacumab infusion to reduce the risk of occurrence and/or the severity of an infusion reaction. Diphenhydramine route of administration (oral or intravenous) should be based on the temporal proximity to the start of the raxibacumab infusion [see Warnings and Precautions ( 5.1 ) , Adverse Rea