Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
6 ADVERSE REACTIONS The following serious adverse reactions are described elsewhere in the labeling: Hemorrhage [see Warnings and Precautions ( 5.1 )] .
Gastrointestinal Perforations [see Warnings and Precautions ( 5.2 )] .
Impaired Wound Healing [see Warnings and Precautions ( 5.3 )] .
Arterial Thromboembolic Events [see Warnings and Precautions ( 5.4 )] .
Hypertension [see Warnings and Precautions ( 5.5 )] .
Infusion-Related Reactions [see Warnings and Precautions ( 5.6 )] .
Worsening of Pre-existing Hepatic Impairment [see Warnings and Precautions ( 5.7 )] .
Posterior Reversible Encephalopathy Syndrome [see Warnings and Precautions ( 5.8 )] .
Proteinuria Including Nephrotic Syndrome [see Warnings and Precautions ( 5.9 )] .
Thyroid Dysfunction [see Warnings and Precautions ( 5.10 )] .
5 WARNINGS AND PRECAUTIONS Hemorrhage : CYRAMZA increases the risk of hemorrhage and gastrointestinal hemorrhage, including severe and fatal events.
Permanently discontinue CYRAMZA in patients who experience severe bleeding.
( 5.1 ) Gastrointestinal Perforations : CYRAMZA increases the risk of gastrointestinal perforation, which can be fatal.
Permanently discontinue CYRAMZA in patients who experience a gastrointestinal perforation.
( 5.2 ) Impaired Wound Healing : Withhold CYRAMZA for 28 days prior to elective surgery.
Like all medications, Cyramza can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: