Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
ADVERSE REACTIONS General Fever, porphyria and dysuria have rarely been reported.
Gout (see PRECAUTIONS ).
Gastrointestinal The principal adverse effect is a hepatic reaction (see WARNINGS ).
Hepatotoxicity appears to be dose related, and may appear at any time during therapy.
GI disturbances including nausea, vomiting and anorexia have also been reported.
Hematologic and Lymphatic Thrombocytopenia and sideroblastic anemia with erythroid hyperplasia, vacuolation of erythrocytes and increased serum iron concentration have occurred rarely with this drug.
Adverse effects on blood clotting mechanisms have also been rarely reported.
Other Mild arthralgia and myalgia have been reported frequently.
Hypersensitivity reactions including rashes, urticaria, and pruritus have been reported.
Fever, acne, photosensitivity, porphyria, dysuria and interstitial nephritis have been reported rarely.
WARNINGS Patients started on pyrazinamide should have baseline serum uric acid and liver function determinations.
Those patients with preexisting liver disease or those at increased risk for drug related hepatitis (e.g., alcohol abusers) should be followed closely.
Pyrazinamide should be discontinued and not be resumed if signs of hepatocellular damage or hyperuricemia accompanied by an acute gouty arthritis appear.
Like all medications, Pyrazinamide can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: