Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
The most common undesirable effects of benzylpenicillin are hypersensitivity reactions, especially skin rashes.
Anaphylactic reactions occurred occasionally, which have sometimes been fatal.
The overall incidence of allergic reactions to penicillin ranges between 1 and 10%.
Anaphylactic reactions occur in approximately 0.05% of patients, usually after parenteral administration.
The following undesirable effects were observed with benzylpenicillin: Blood and lymphatic system disorders - Eosinophilia and hemolytic anemia (both with immunological basis), leukopenia and thrombocytopenia.
These effects are usually reversible after discontinuation of treatment.
Immune system disorders - Hypersensitivity reactions to penicillin cause a wide variety of clinical syndromes.
Immediate reactions include anaphylaxis, laryngeal edema, angioedema, urticaria and maculopapular rashes.
Late reactions include hemolytic anemia and immune complex self-limited sickness-like reactions, characterized by fever, malaise, urticaria, arthralgia, myalgia, lymphadenopathy and splenomegaly.
In order to determine which patients will probably develop severe allergic reactions, hypersensitivity skin tests may be used.
Lentocilin S suspension for injection should ONLY be administered by INTRAMUSCULAR ROUTE.
To avoid injury, Lentocilin S suspension should not be administered by intravenous, intraarterial or subcutaneous route, in the adipose layer, into or near a peripheral nerve or blood vessel.
Before injecting the suspension, the position of the needle should be controlled by aspiration.
If blood shows up in the syringe, pull back the needle and inject on another site.
Administer Lentocilin S suspension EXCLUSIVELY by DEEP INTRAMUSCULAR INJECTION in the external upper quadrant of the buttock.
Like all medications, Lentocilin can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: