5 known interactions • 4 major • 1 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Anti-arrhythmics, beta-blockers, calcium channel blockers, digoxin
Additive bradycardic effects at first dose. Do not initiate ozanimod in patients on these medications without cardiology evaluation and monitoring. Extended first-dose observation required.
MAO inhibitors (selegiline, rasagiline, phenelzine, tranylcypromine)
Contraindicated. Ozanimod active metabolite inhibits MAO-B. Co-administration with MAO-A or non-selective MAO inhibitors may cause serotonin syndrome or hypertensive crisis.
Tyramine-rich foods (aged cheese, cured meats, wine)
Avoid excessive tyramine consumption. MAO-B inhibition by active metabolite may impair tyramine metabolism; large tyramine doses risk hypertensive crisis.
Live attenuated vaccines
Avoid during treatment and for 3 months after discontinuation.
CYP2C8 inhibitors (gemfibrozil, clopidogrel)
May significantly increase ozanimod active metabolite exposure. Avoid combination.
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Ozanimod. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.