Complete adverse effect profile including incidence rates and management
Important Safety Information
This is not a complete list of all possible side effects. Contact your healthcare provider if you experience any unexpected symptoms. For serious or life-threatening side effects, seek emergency medical attention immediately.
6 ADVERSE REACTIONS • Most common adverse reactions to neostigmine during treatment: bradycardia, nausea, vomiting, blurred vision and photophobia.
( 6 ) • Most common adverse reactions to glycopyrrolate are related to anticholinergic pharmacology and may include xerostomia (dry mouth);
urinary hesitancy and retention;
blurred vision and photophobia due to mydriasis (dilation of the pupil);
cycloplegia;
increased ocular tension;
tachycardia;
bradycardia;
palpitation;
and decreased sweating.
5 WARNINGS AND PRECAUTIONS • Bradycardia : consideration should be given to administration of glycopyrrolate prior to neostigmine (i.e., as separate products) in patients with bradycardia or in patients in whom bradycardia, a known risk of neostigmine methysulfate, may cause hemodynamic instability.
( 5.1 ) • Serious Reactions with Coexisting Conditions : Use with caution in patients with, coronary artery disease, cardiac arrhythmias, recent acute coronary syndrome, hyperthyroidism or myasthenia gravis.
( 5.2 ) • Hypersensitivity : Because of the possibility of hypersensitivity, medications to treat anaphylaxis should be readily available.
( 5.3 ) • Neuromuscular Dysfunction : Can occur if large doses of PREVDUO ® are administered when neuromuscular blockade is minimal;
reduce dose if recovery from neuromuscular blockade is nearly complete.
Like all medications, Prevduo can cause side effects. However, not everyone who takes this medication will experience them. Many side effects are dose-dependent and may improve as your body adjusts to the medication. Others may require dose adjustment or medical attention.
Contact your healthcare provider promptly if you experience:
Seek immediate emergency medical care if you experience signs of: