2 known interactions • 1 major • 1 moderate • 0 minor
Always disclose all medications to your healthcare providers — prescription medicines, OTC medications, vitamins, and herbal supplements. This list may not include every possible interaction. Use our Medicine Interaction Checker to screen your complete medication list.
Potentially life-threatening or causing permanent damage. Avoid combination.
May worsen condition or require dose adjustment. Monitor closely.
Usually limited clinical effect. Manage with routine monitoring.
Opioids
Opioid antagonism - prevents opioid effects and may cause withdrawal
Management: Must wait 7-10 days after last opioid before starting naltrexone
Alcohol
Additive liver toxicity
Management: Avoid excessive alcohol
Always ask your pharmacist about potential interactions with food, alcohol, and supplements specific to Naltrexone. Some medicines have significant interactions with grapefruit juice, high-fat meals, dairy products, or vitamin K-rich foods.