Complete dosing information for methylene blue
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
Methemoglobinemia (IV): 1–2 mg/kg (0.1–0.2 mL/kg of 1% solution) IV over 5–30 minutes; may repeat dose of 1 mg/kg after 30–60 minutes if inadequate response; maximum cumulative dose generally 7 mg/kg (doses above 4 mg/kg associated with paradoxical methemoglobin formation). Ifosfamide encephalopathy treatment: 50 mg orally every 4–6 hours or 50 mg IV every 4 hours until encephalopathy resolves. Ifosfamide encephalopathy prophylaxis: 50 mg orally three times daily on days of ifosfamide administration and for 24 hours after. Vasoplegic syndrome (off-label): 1–2 mg/kg IV over 20–60 minutes as a single dose; continuous infusion of 0.25–2 mg/kg/hour has been used in refractory cases. Urinary antiseptic (oral tablets): 55–130 mg orally two to three times daily with a full glass of water.
Methemoglobinemia (IV, pediatric): 1–2 mg/kg (0.1–0.2 mL/kg of 1% solution) IV over 5–30 minutes; dosing is weight-based and identical to adult dosing on a mg/kg basis. Use with caution in neonates and infants under 3 months due to immature NADPH-methemoglobin reductase activity and increased risk of methemoglobin formation at higher doses. Not approved for use in pediatric patients under 6 months for most indications; use in neonates (G6PD-deficiency must be ruled out prior to use).