Complete dosing information for metformin hydrochloride
Medical guidance required: Dosing information here is for educational purposes. Your healthcare provider will determine the appropriate dose based on your specific condition, kidney function, other medications, and medical history. Never adjust your dose without consulting your doctor or pharmacist.
Initial: 500 mg twice daily or 850 mg once daily with meals. Increase by 500 mg weekly or 850 mg every 2 weeks. Usual maintenance: 1500–2000 mg/day. Maximum: 2550 mg/day (IR) or 2000 mg/day (ER).
Children ≥10 years: 500 mg twice daily initially. Maximum: 2000 mg/day.
eGFR 30–45 mL/min/1.73m²: Use with caution, reduce dose. eGFR <30: Contraindicated.
Avoid in hepatic impairment due to risk of lactic acidosis.